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FLASH GENE
Symbol EIF3F contributors: mct - updated : 13-11-2013
HGNC name eukaryotic translation initiation factor 3, subunit F
HGNC id 3275
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Hearing/Equilibriumearinnercochlea highly
Lymphoid/Immunelymph node   highly
 tonsils   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatum  highly
cell lineage
cell lines Hela cells
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal rich protein region
  • a MPN (JAB/Mov34) domain
  • a conserved TOS motif that during terminal muscle differentiation connects MTOR/raptor complex
  • highly conserved C-terminal domain is implicated for FBXO32-directed polyubiquitination and proteasomal degradation
  • mono polymer heteromer , complex
    HOMOLOGY
    interspecies homolog to murine Eif3f (93.5 pc)
    homolog to rattus Eif3s5 (93.2 pc)
    Homologene
    FAMILY
  • eukaryotic translation initiation factor family
  • peptidase M67 family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    basic FUNCTION
  • stabilizing initiator Met tRNA (TRIMs) binding to 40S subunits
  • promoting the association of Met-tRNA and mRNA
  • plays a major role for proper activity of MTOR to regulate skeletal muscle size
  • expression pattern of EIF3F during the cell cycle confirms that this gene is cell division related
  • one of the 13 subunits of the translation initiation factor complex EIF3 required for several steps in the initiation of mRNA translation
  • plays a central role in skeletal muscle size maintenance
  • CELLULAR PROCESS protein, translation/synthesis
    protein, translation regulation
    PHYSIOLOGICAL PROCESS
    text regulation of translational initiation
    PATHWAY
    metabolism
    signaling
    a component
  • component of the EIF3 multiprotein complex 600kDa (composed of at least 13 different subunits)
  • INTERACTION
    DNA
    RNA binding to the 40S ribosome
    small molecule
    protein
  • associates with the complex p170-eIF3
  • interacting with CDK11
  • interacting with FBXO32 (highly conserved C-terminal domain is implicated for FBXO32-directed polyubiquitination and proteasomal degradation)
  • promotes rRNA degradation through direct interaction with heterogeneous nuclear ribonucleoprotein HNRNPK
  • MSH4 interacting protein (EIF3F functions not only in translation but also in the regulation of apoptosis and tumorigenesis)
  • target of the E3 ubiquitin ligase FBXO32 for proteasome-mediated breakdown under atrophic conditions
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS