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FLASH GENE
Symbol EIF3H contributors: mct - updated : 05-03-2011
HGNC name eukaryotic translation initiation factor 3, subunit H
HGNC id 3273
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon highly
Lymphoid/Immunelymph node    
 spleen   highly
Reproductivefemale systemuteruscervix highly
Visualeye    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
one JAB/MPN domain
HOMOLOGY
interspecies homolog to murine Eif3s3
Homologene
FAMILY eukaryotic translation initiation factor family
CATEGORY RNA associated
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic,ribosome
basic FUNCTION
  • eukaryotic translation initiation factor
  • stabilizing initiator Met tRNA (TRIMs) binding to 40S subunits
  • regulates cell growth and viability, and overexpression of the gene may provide growth advantage to the cancer cells
  • promoting the association of Met-tRNA and mRNA
  • high EIF3H levels directly stimulate protein synthesis, resulting in the establishment and maintenance of the malignant state in cells
  • plays a central role in translation initiation
  • has specific as well as redundant functions during early development
  • CELLULAR PROCESS nucleotide, transcription, initiation
    protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of the EIF3 multiprotein complex, 600kDa
    INTERACTION
    DNA
    RNA binding to the 40S ribosome
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    breast and prostate cancer, hepatocellular carcinoma
    tumoral   amplification    
    with MYC, are frequently coamplified in non-small cell lung cancer and a high copy number correlates with increased epidermal growth factor receptor tyrosine kinase inhibitors sensitivity
    Susceptibility to colorectal cancer(CRC)
    Variant & Polymorphism SNP , other
  • increasing the risk of colorectal cancer
  • rs16888589 increases the expression of EIF3H and increased expression of this gene increases CRC growth
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS