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FLASH GENE
Symbol DBF4 contributors: mct/npt - updated : 04-01-2012
HGNC name DBF4 homolog (S. cerevisiae)
HGNC id 17364
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node   highly
Reproductivemale systemtestis  highly
cell lineage
cell lines
fluid/secretion
at STAGE
cell cycle     cell cycle, interphase, S, checkpoint, G1S
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a short N-terminal region that targets CDC7-DBF4 kinase to CDC5
  • putative site for phosphorylation by CDK
  • PEST protease cleavage sites, nuclear localization signals (NLS)
  • a short-looped zinc finger-like domain
  • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae DBF4 kinase
    Homologene
    FAMILY
    CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • essential for the G1/S transition and initiation of DNA replication to Saccharomyces
  • involved in proliferation, and aggressiveness of prolactin pituitary tumors (Wierinckx 2007)
  • CDC7-DBF4 is a conserved protein kinase required for the initiation of DNA replication
  • CDC7-DBF4 prevents inappropriate exit from mitosis by inhibiting Polo kinase and functions in the spindle position checkpoint
  • CELLULAR PROCESS cell cycle, checkpoint
    nucleotide, replication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of a complex with CDC7 capable of phosphorylating MCM2 protein
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to CDC7 (regulatory partner of the CDC7 serine/threonine protein kinase, which is essential for the activation of individual ori sites throughout S phase in eukaryotic cells)
  • CDC7/DBF4 heterodimer is a novel interactor of PSIP1 (
  • CDC7-DBF4 interaction with CDC5
  • bipartite interaction between CDC7 and DBF4 subunits facilitates ATP binding and substrate recognition by the CDC7 kinase
  • cell & other
    REGULATION
    Other regulated by by transcription and protein degradation.
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS