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FLASH GENE
Symbol ATF1 contributors: shn/npt - updated : 10-07-2019
HGNC name activating transcription factor 1
HGNC id 783
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbraindiencephalonhypothalamus highly
 brainlimbic systemhippocampusdentate gyrus 
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • basic leucine zipper (bZIP) protein
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies ortholog to Atf1, Mus musculus
    ortholog to ATF1, Pan troglodytes
    ortholog to atf1, Danio rerio
    ortholog to Atf1, Rattus norvegicus
    Homologene
    FAMILY
  • CREB protein family
  • bZIP family
  • ATF subfamily
  • CATEGORY transcription factor , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • can mediate both Ca2+ and cAMP transcriptional responses (Liu et al, 1993)
  • mediating the E1A responsiveness
  • activating transcription factor 1
  • having a role as a hypoxia-responsive trans-activator
  • photoreceptors degeneration leads to phosphorylation and increase expression of CREB1/ATF1 complex which is associated with a neuroprotective outcome in photoreceptors (Beltran et al, 2009)
  • markedly affected the resistance to heat shock
  • functions as an oncogene by affecting cell apoptosis, and two causal SNPs, located in the ATF1 promoter and first intron, synergistically predispose to colorectal cancer risk through a promoter-enhancer interaction mediated by SP1 and GATA3
  • important role of ATF1 in the development of colorectal cancer
  • is a novel pluripotent regulator in human embryonic stem cells (hESCs)
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimers with other ATF*, and a PKID domain (phosphorylated kinase-inducible domain)
  • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • casein kinase II, CKII (Yamaguchi et al, 1998)
  • human GA-binding protein (hGABP) alpha (Sawada et al, 1999)
  • breast cancer 1 early onset, BRCA1 (Houvras et al, 2000)
  • ATF1 mediates HMOX1 induction by heme and drives macrophage adaptation to intraplaque hemorrhage
  • is a negative transcriptional regulator of SOX2 gene expression
  • cell & other
    REGULATION
    Other phosphorylated by MKS1 and MKS2 (Wiggin et al, 2002)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   translocation    
    involved in malignant melanoma or clear cell sarcoma of soft tissues with translocation t(12;22)(q13;q12) (see EWSR1)
    tumoral        
    Angiomatoid fibrous histiocytoma (AFH) due to EWSR1-ATF1 fusion genes
    tumoral        
    angiomatoid fibrous histiocytoma due to fusion of the FUS and ATF-1 genes
    tumoral fusion      
    with EWSR1 is a novel and consistent finding in hyalinizing clear-cell carcinoma of salivary gland
    Susceptibility
  • to clear cell sarcoma of tendons and aponeuroses
  • to colorectal cancer
  • Variant & Polymorphism SNP
  • SNP rs11169571 and SNP rs11169552 are associated with risk of colorectal cancer
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS