protein
| targeting of PPP1CC to F-actin by neurabins in intact cells requires both the canonical PP1-binding motif and an auxiliary PPP1CC-selectivity determinant |
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interact with, and dephosphorylate AXIN1, leading to its destabilization and DAB2 functions upstream of PPP1CC to block the interaction between AXIN1 and PPP1CC, inhibiting AXIN1 dephosphorylation and thereby stabilizing its expression, ultimately leading to inhibition of Wnt/beta-catenin |
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interacts with IKZF1 via a conserved PP1 binding motif, RVXF, in the C-terminal end of the IKZF1 protein |
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reciprocal relationship between the levels of the PPP1CC and its regulator PPP1R11, suggesing that complex formation between these polypeptides in testis may prevent proteolysis of PPP1R11 and thus, germ cell apoptosis |
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binding of PPP1CC to CENPE required for the stable attachmentof these chromosomes |
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PLK1 controls the NEK2-PPP1CC antagonism in centrosome disjunction |
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dependent manner |
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PPP1CC interacts with and dephosphorylates WWC1 |
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SMN complex and its component GEMIN8 interact directly with protein phosphatase PPP1CC |
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binding of actin to PHACTR4 influences the activity of PPP1CC and the phosphorylation status of one of its downstream targets, cofilin |
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TCTEX1D4 interacts with the different spliced isoforms of PPP1CC |
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is a positive regulator of MYD88-dependent proinflammatory innate immune activation |
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physically interacts with the E3 ubiquitin ligase TRAF6, and enhances the activity of TRAF6 towards itself and substrates such as IKBKG |
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AHCTF1 docks the catalytic subunit of protein phosphatase 1 (PPP1CC) to direct kinetochore disassembly-dependent chromosome segregation during oocyte meiosis I and nuclear assembly during the transition from M phase to interphase |