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FLASH GENE
Symbol TNFAIP2 contributors: npt - updated : 27-01-2010
HGNC name tumor necrosis factor, alpha-induced protein 2
HGNC id 11895
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Lymphoid/Immunespleen    
 thymus   predominantly
Reproductivefemale systemuterus   
 male systemprostate   
Respiratorylung    
Urinarybladder    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone   
cell lineage
cell lines in marrow of acute myelogenous leukemia
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • single N linked glycosylation site
  • stretches of glutamate, lysine alanine near the N terminus
  • four glutamines near the C terminus
    • HOMOLOGY
    interspecies ortholog to murine Tnfaip2
    Homologene
    FAMILY
  • SEC6 family
    • CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • playing a role as a mediator of inflammation and angiogenesis
  • playing a role in myeloid development and is a target gene of PML-RARalpha in acute promyelocytic leukemia (Rusiniak 2000)
    • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by retinoic acid
    induced by PML-RARA in acute myelogenous leukemia (Rusiniak 2000)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in acute promyelocytic leukemia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS