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FLASH GENE
Symbol TPT1 contributors: mct/npt/pgu - updated : 23-03-2010
HGNC name tumor protein, translationally-controlled 1
HGNC id 12022
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   highly
Digestiveintestinesmall intestine   
 liver   highly
Reproductivemale systemprostate  highly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/lining   
Lymphoid    
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductiveepithelial cell
Skin/Tegumentkeratinocyte
cell lineage
cell lines
fluid/secretion prostatic fluid
at STAGE
physiological period embryo, fetal
cell cycle     cell cycle, interphase, M
Text liver
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminus (AAs 1-72) is required for its Ca2+-binding
  • HOMOLOGY
    interspecies homolog to rattus Tpt1 (95,93 pc)
    homolog to murine Tpt1 (95,93 pc)
    Homologene
    FAMILY
  • TCTP family
  • CATEGORY enzyme , protooncogene
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus
    text
  • in prostate epithelial cells detected the protein in the cytoplasm in interphase and colocalized with tubulin during mitosis
  • present both in the cytosol and nucleus
  • colocalizes with CHFR to the mitotic spindle
  • basic FUNCTION
  • preferentially synthesized in cells during the early growth phase of some types of tumor but which is also expressed in normal cells
  • antiapoptotic protein involved in cell survival and apoptosis regulation
  • Na/K-ATPase-suppressive activity
  • possesses potent anti-apoptotic activity
  • intracellular Ca2+ scavenger, protecting cells against Ca2+-dependent apoptosis by binding and sequestering Ca2+ from the downstream Ca2+-dependent apoptotic pathways
  • involved in TSC22D1 destabilization via their interaction
  • plays a very modest role in thymocyte development, but is critical for peripheral T cell maintenance and TCR-mediated cell proliferation
  • may belong to a novel small molecular weight heat shock protein with chaperone-like activity
  • identified on the surface of nanovesicles purified from medium conditioned by apoptotic endothelial cells, and TCTP-bearing nanovesicles are a novel component of the paracrine apoptotic program of potential importance in vascular repair
  • survival factor that protects cancer cells from oxidative stress-induced cell-death
  • CELLULAR PROCESS cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    bind Ca2+ (must bind Ca2+ in order to protect cells against Ca2+-dependent apoptosis)
    protein
  • EEF1D
  • interacting with TSC22D1
  • binding to dihydroartemisinin (DHA)
  • interacting with STEAP3
  • interacts with RHEB and activates the MTOR pathway
  • possible CHFR-interacting partner (CHFR-TPT1 interaction is stable throughout the cell cycle, but it could be diminished by the complete depolymerization of the microtubules, providing a possible mechanism where CHFR could be the sensor that detects microtubule disruption and then activates the prophase checkpoint)
  • cell & other
    REGULATION
    induced by regulated by CREB transcription factors
    inhibited by SNX6
    Other reduced cellular levels in varieties of cells after binding to dihydroartemisinin and increased ubiquitination
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in gastric cancer
    tumoral     --over  
    in many cancers
    constitutional     --low  
    may result in sequestration of active cofilin by a monomeric pool of actin
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    for fortilin-overexpressing cancers
    cancer  
    is a "stress hallmark" that may be exploited as a therapeutic target to decrease the resistance of cancer cells to anticancer therapy
    ANIMAL & CELL MODELS