basic FUNCTION
| playing an essential role in spliceosomal snRNP assembly in the cytoplasm required for pre-mRNA splicing in the nucleus |
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plays an important role in stabilizing the survival of motor neuron complex |
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core protein that is essential for the formation of the SMN complex |
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plays an important role in snRNP assembly through the stabilization of the SMN oligomer/complex via novel self-interaction |
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stabilize functional multimer forms of integrase, thereby promoting the assembly of integrase and reverse transcriptase on viral RNA to allow efficient reverse transcription, which is a prerequisite for efficient HIV-1 infection |
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involved in spliceosome biogenesis |
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enhances the RAD51–DNA complex formation by inhibiting RAD51 dissociation from DNA, and thereby stimulates RAD51-mediated homologous pairing |
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regulates HR (homologous recombination) as a novel RAD51 mediator |
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role in regulating the RAD51 recombinase and thereby promoting HR-dependent repair |
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dual functions: the regulation of spliceosomal snRNP formation and the control of RAD51-dynamics at DNA damage |
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SMN1-GEMIN2 complex plays a role in homologous recombination, in addition to spliceosomal snRNP assembly |