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FLASH GENE

Symbol

GDA

contributors: - updated : 04-09-2007

HGNC name	guanine deaminase
HGNC id	4212

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       highly Nervous brain       highly Reproductive female system uterus     highly Respiratory lung         Urinary kidney tubule convoluted tubule proximal tubule

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial absorptive excretory digestive epithelium (mucosa)     Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Digestive hepatocyte Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

Text	in developing dendrites

PROTEIN

PHYSICAL PROPERTIES		acid
STRUCTURE

motifs/domains	a nine residue N terminal motif that is present in other aminohydrolases and amidohydrolases
	zinc binding, collapsin response mediator protein (CRMP) homology domain
	PSD-95, Discs large, zona occludens-1 binding domain

mono polymer

homomer , dimer

HOMOLOGY

interspecies	homolog to Drosophila CG18143
	homolog to C.elegans T20D4.9
	homolog to rattus guanine aminohydrolase
	homolog to murine Gda guanine deaminase

intraspecies

homolog to CRMP1,weakly

Homologene

FAMILY

ATZ/TRZ family

CATEGORY

enzyme , regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION	catalyzing the hydrolytic deamination of guanine
	producing xanthine and ammonia
	may have a role in clustering neurotransmitter receptors
	may influence synaptic development and plasticity by regulating postsynaptic protein sorting
	regulates dendrite patterning in hippocampal neurons by promoting microtubule assembly
	decreases PSD-95 family member localization and regulates dendrite number

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development

text	neurogenesis, synaptic development and plasticity

PATHWAY

metabolism

nucleic , purine/pyrimidine

signaling

purine nucleotide catabolism

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	zinc Zn2+ (one ion per subunit)

protein	regulating DLG4 (PSD-95) postsynaptin targeting
	binds directly to tubulin heterodimers and promotes microtubule polymerization, via its CRMP homology domain to promote microtubule assembly
	interacting with SNAPAP (coiled-coil domain (H2) of SNAPAP is required for GDA binding)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS