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FLASH GENE
Symbol SHROOM4 contributors: mct - updated : 26-10-2011
HGNC name shroom family member 4
HGNC id 29215
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
 mouthtongue   
 pharynx    
Endocrinethyroid    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text
  • broadly expressed in developing epithelial organs, and the epithelial cells that express SHROOM are elongated
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N-terminal PDZ domain
  • a C-terminal unique domain ASD2 (Apx/Shroom domain 2), characteristic signature of the SHRM family
  • HOMOLOGY
    interspecies ortholog to murine Shroom4 (83 pc)
    Homologene
    FAMILY SHROOM family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    basic FUNCTION
  • putatively involved in the regulation of amiloride-sensitive sodium channel activity
  • critical determinant of the cellular architecture requirig for prosper neurulation
  • is a potential regulator of cytoskeletal architecture that may play an important role in vertebrate development
  • SHROOM family proteins govern epithelial cell behaviors by coordinating the assembly of both microtubule and actin cytoskeletons
  • PDZ-domain protein involved in the regulation and maintenance of cytoskeletal architecture by binding to actin
  • SHROOM family proteins play an important role in the morphogenesis of several different epithelial tissues during development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text
  • regulator of cell shape changes in the developing nervous system
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SDSX
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mutated in mouse Shrm causing exencepaly, acrania, facial clefting and spina bifida, all of wich can be attributed to failes neural tube closure