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FLASH GENE
Symbol CIAO1 contributors: SGE/npt - updated : 11-03-2016
HGNC name cytosolic iron-sulfur protein assembly 1 homolog (S. cerevisiae)
HGNC id 14280
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven WD40 repeats
  • HOMOLOGY
    interspecies homolog to murine Ciao1 (95.0pc)
    homolog to rattus Ciao1 (94.4pc)
    Homologene
    FAMILY
  • WD repeat CIA1 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • functional modulator of the transcriptional activation function Wilms tumor suppressor gene (WT1)
  • required for the maturation of extramitochondrial Fe/S proteins (Srinavasan 2007)
  • apoptosome-activating protein
  • in the CIA pathway, CIAO1 cooperates with CIAO2A, CIAO2B, and MMS19 targeting factors to form various complexes that mediate the dedicated maturation of specific Fe/S recipient proteins
  • CIAO1 an essential component of the cytosolic iron-sulfur protein assembly (CIA) machinery, is crucial for Fe/S cluster insertion into RSAD2 and hence for RSAD2 antiviral activity
  • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • essential component of the cytosolic Fe/S protein assembly machinery
  • FAM96B-CIAO1-MMS19 complex binds to and facilitates assembly of most cytosolic-nuclear Fe/S proteins
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with WT1
  • CIAO2B and CIAO1 associate with the C terminus of MMS19 (
  • CIAO2A and CIAO2B form mutually exclusive complexes with CIAO1 to allow for selective interaction with different target Fe/S protein
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS