basic FUNCTION
| play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway |
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exhibiting characteristics of a WNT receptor, involved in regulation of the WNT signaling pathway |
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controles vascular development in the retina and inner ear |
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modulates apoptosis and enhances WNT3A induced beta-catenin stability in myeloid progenitor cells |
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an essential role in retinal endothelial cells |
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required for vascular integrity in the cerebellum |
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Fz4/Lrp5 signaling could play a role in vascular growth, remodeling, and maintenance in a variety of normal and pathologic contexts beyond the retina |
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plays a crucial role in vascular development in the retina |
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required for physiological and pathologic angiogenesis in the retina, for regulation of retinal endothelial cell differentiation, and for maintaining the integrity of the mature blood-retina barrier ( |