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FLASH GENE
Symbol CPNE1 contributors: mct - updated : 17-12-2019
HGNC name copine I
HGNC id 2314
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveintestinelarge intestinecolon moderately
 mouth   moderately
 stomach   moderately
Endocrinethyroid   moderately
Lymphoid/Immunespleen    
 thymus   moderately
 tonsils   predominantly
Nervousbrain    
Reproductivefemale systemovary  moderately
 female systemuteruscervix moderately
Respiratoryrespiratory tracttrachea  highly
Skin/Tegumentskin   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  moderately
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticneutrophil
cell lineage
cell lines
fluid/secretion highly in lymph
at STAGE
physiological period fetal, pregnancy
Text liver
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two Ca(2+)- and phospholipid-binding domains known as 'C2 domains', two tandem C2 domains at the N-terminus
  • one WWFA domain
  • a C terminal region distantly related to the A domain, an A domain at the C&
  • 8209;terminus
    HOMOLOGY
    interspecies homolog to rattus Cpne1 (92.1pc)
    homolog to murine Cpne1 (91.6 pc)
    Homologene
    FAMILY
  • copine family
  • CATEGORY transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,nucleus,nucleoplasm
    intracellular,nuclear envelope
    text
  • secretory vesicle
  • cytosol of neutrophils
  • basic FUNCTION
  • potentially involved in regulating membrane trafficking
  • playing a role in protein-protein interactions
  • CPNE1 plays a key role in the regulation of NSC (neural stem cell) functions through the activation of AKT1-MTOR signaling pathway during brain development
  • CPNE1 plays a vital role in regulating cell differentiation
  • is a highly conserved calcium-dependent phospholipid-binding protein and may function in regulating signal transduction and membrane trafficking
  • CPNE1 is an oncogene in non-small cell lung cancer (NSCLC) and serves an important role in tumorigenesis of NSCLC progression
  • CPNE1 and STC2, were confirmed to be modifiers of in vitro myogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text
  • vesicular transport
  • membrane trafficking
  • PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, other,
  • binding to phosphatidylserine in a calcium-dependent manner
  • protein
  • interacting with RBM12
  • COPS5 appears to directly interact with CPNE1
  • COPS5 activates the neuronal differentiation ability of CPNE1 through the binding of C2A domain in CPNE1 with MPN domain in COPS5
  • CPNE1 binds with various intracellular proteins via its A domain and C domain
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in glaucomatous trabecular meshwork (TM) cells when compared to normal ones
    tumoral     --over  
    in the osteosarcoma tissues and cell lines
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • is a valuable prognostic marker for evaluating recurrence-free survival and is positively related to TRAF2 expression in prostate cancer
  • Therapy target
    ANIMAL & CELL MODELS