basic FUNCTION
| FA-associated nuclease, that binds directly to monoubiquitinated FANCD2, resolving a decade-long puzzle regarding the function of this FANCD2 modification |
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nuclease involved in the processing of mitomycin C (MMC)- and cisplatin-induced DNA damage, to which it is recruited by ubiquitylated FANCD2 |
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promotes interstrand cross-linking (ICL)repair in a manner strictly dependent on its ability to accumulate at or near sites of DNA damage and that relies on mono-ubiquitylation of the ID complex |
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repair nuclease that is recruited to sites of crosslink damage in part through binding the ubiquitinated ID complex through its UBZ domain |
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required for the late stages of ICL repair |
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required for the processing of recombination intermediates that arise predominantly during the metabolism of damage induced by ICL-generating agents |
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endonuclease that may act together with other repair proteins to mediate endonucleolytic digestion of cross-linked DNA structures and, thus, generate ends that can serve as substrates for HR repair |
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might be involved in homologous recombination and in the maintenance of chromosomal stability |
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it is possible that FAN1 is functionally at least partially redundant with other, as yet unidentified, nucleases |
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displays both endonuclease and exonuclease activity and this ubiquitin-mediated recruitment focuses the nuclease activity of FAN1 to the site of the ICL |
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structure-selective DNA repair nuclease with 5prime flap endonuclease activity, involved in the repair of interstrand DNA crosslinks |
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its activity on asymmetric repair intermediates is mediated by an atypical monomeric virus-type replication-repair nuclease domain |
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is a new crucial replication fork recovery factor |
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FAN1 nuclease activity at stalled replication forks requires tight regulation: too little inhibits fork restart, whereas too much causes fork degradation |
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is a DNA structure-specific endonuclease that is considered to be involved in DNA incision at the stalled replication fork |
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FAN1 recruitment enables processing of stalled forks that is essential for genome stability and health |
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FAN1 is likely protective in the context of an expanded HTT CAG repeat |
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encodes a protein that participates in DNA interstrand cross-link (ICL) repair |
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FAN1 normally functions to stabilize the expanded CAG repeat |