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FLASH GENE
Symbol PLXND1 contributors: mct/npt - updated : 28-11-2018
HGNC name plexin D1
HGNC id 9107
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal SEMA homology domain
  • two typical and atypical cysteine rich domains sharing homology with the scatter factor reception (MET family) MRS
  • a single transmembrane segment (1TM)
  • a sorting motif that interacts with the adaptor protein GIPC1 to facilitate transport to recycling endosomes
  • HOMOLOGY
    Homologene
    FAMILY
  • calcium-dependent cell adhesion molecule family
  • plexin family
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • receptors for multiple (and perhaps all) classes of semaphorins, either alone or in combination with neuropilins, and trigger a novel signal transduction pathway controlling cell repulsion (Tamagnone 1999)
  • its expression during tumor development is strongly correlated with both invasive behavior and metastasis (Roodink 2008)
  • important role in directing migration of maturing thymocytes via modulation of biological responses to chemokine gradients (Choi 2008)
  • novel role of SEMA3E-PLXND1 function in modulating angiogenesis via a VEGFA-induced feedback mechanism (pMID: 21724832)
  • potential role of PLXND1 in cervical cancer-associated angiogenesis
  • PLXND1 operates in a cell context-specific fashion, mediating different synaptogenic outcomes depending upon neuron type
  • PLXND1 is a pivotal mediator of this signaling axis downstream of NOTCH in prostate cancer cells
  • PLXND1 signaling controls likely filopodium-like lateral protrusion (FLP) formation and the termination of neuronal migration through a precise control of microtubule dynamics.
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • receptor for the semaphorin 7A (SEMA7A)
  • semaphorin 3E (Sema3E), one of the ligands for PLXND1, has previously been correlated with invasive behavior and metastasis, suggesting that the PLXND1-SEMA3E interaction may play a role in tumor progression (Roodink 2008)
  • receptor of SEMA3E (interacting during the formation of proprioceptive sensory–motor reflex circuits) (Pecho-Vrieseling 2009)
  • SH3BP1 mediates SEMA3E-induced cell collapse through interaction with PLXND1 and regulation RAC1 activity
  • SEMA3E/PLXND1 modulates Immunological synapse (IS) formation and Ag-scanning activities of thymocytes within thymic tissues
  • mesenchymal SEMA3D guides outgrowth of the common cardinal vein via repulsion and signals through PLXND1
  • SEMA3G induces cell collapse in an NRP2/PLXND1-dependent manner
  • GIPC1-mediated endocytic trafficking regulates PLXND1 signaling, and PLXND1 binding to GIPC1 releases the autoinhibition, promoting its interaction with myosin VI
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in metastatic melanomas (Roodink 2008)
    tumoral       gain of function
    in melanoma, breast, colon, ovarian and prostate cancers
    constitutional germinal mutation      
    in PLXND1 and REV3L that are responsible for a proportion of Möbius syndrome (MBS) patients suggesting that de novo mutations in other genes might account for other MBS patients
    constitutional germinal mutation      
    in isolated truncus arteriosus
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • might be a potential cervical cancer biomarker
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    NOTCH1-PLXND1 signaling axis may be targeted to impair prostate cancer cell invasiveness and metastasis
    ANIMAL & CELL MODELS
  • PlxnD1(-/-) mice exhibited defective germinal center (GC) reactions during T-dependent immune activation