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FLASH GENE
Symbol PLXNC1 contributors: mct/npt - updated : 16-03-2010
HGNC name plexin C1
HGNC id 9106
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Reproductivefemale systemplacenta   
Respiratorylung    
Skin/Tegumentskin   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunedendritic cell
Nervousneuron
Skin/Tegumentmelanocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal SEMA homology domain
  • two cysteine rich domains sharing homology with the scatter factor reception (MET family) MRS
  • a single transmembrane segment (1TM)
  • HOMOLOGY
    Homologene
    FAMILY
  • calcium-dependent cell adhesion molecule family
  • plexin family
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • virus-encoded receptor for the semaphorin 7A (SEMA7A)
  • may be involved in the regulation of leukocyte movement
  • potential tumor suppressor protein in melanoma progression, and loss of Plexin C1 expression may promote melanoma invasion and metastasis through loss of inhibitory signaling on cofilin activation (Scott 2009)
  • involved in neural and vascular patterning
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • receptor for SEMA7A
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in metastatic melanoma compared with primary melanoma (possibility that the Plexin C1 receptor is a tumor suppressor protein for melanoma) (Lazova 2009)
    constitutional     --over  
    in proliferating hemangiomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS