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FLASH GENE
Symbol CD53 contributors: - updated : 14-12-2005
HGNC name CD53 molecule
HGNC id 1686
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node   moderately
 spleen   highly
 thymus   predominantly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticmonocyte
Blood/Hematopoieticneutrophil
Lymphoid/ImmuneB cell
Lymphoid/Immunemacrophage
Lymphoid/ImmuneT cell
cell lineage
cell lines
fluid/secretion blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophilic Hydrophobic
STRUCTURE
motifs/domains
  • four transmembrane hydrophobic domains
  • a major extracellular hydrophilic loop containing 2 potential N-glycosylation sites
  • conjugated GlycoP
    mono polymer complex
    HOMOLOGY
    interspecies ortholog to rattus Cd53
    ortholog to murine Cd53
    homolog to drosophila Tsp39D
    Homologene
    FAMILY transmembrane 4 superfamily member, tetraspanin (TM4SF)
    CATEGORY antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • integral to plasma membrane
  • basic FUNCTION
  • may be involved in growth regulation in hematopoietic cells
  • contributing to the transduction of CD2-generated signals in T cells and natural killer cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
  • involved in a complex with integrins
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS