protein
| MITF, TFE3 and TFEC ( |
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TFE3 and TFEB are cell type-specific leukemia inhibitory factor-responsive activators of E-cadherin (CDH1) |
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tends to bind to the core promoters of its targets genes |
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TFEB targets control multiple sequential steps of at least five degradation pathways, including the degradation of heparan and keratan sulfate * |
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also targets genes encoding the subunits of the vacuolar proton pump, which creates and maintains the lysosomal acidic environment |
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interacting with MTOR (coordinately regulates TFEB phosphorylation and nuclear localization and in a manner dependent on both TFEB and ATP6VH, MTOR promotes endocytosis) |
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interacting with the Rag GTPase complex, which senses lysosomal amino acids and activates MTOR, and is both necessary and sufficient to regulate starvation- and stress-induced nuclear translocation of TFEB |
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PPARGC1A promoted HTT turnover and the elimination of protein aggregates by activating TFEB, a master regulator of the autophagy-lysosome pathway |
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interaction of TFEB with active Rag heterodimers promoted recruitment of TFEB to lysosomes, leading to MTOR-dependent phosphorylation and inhibition of TFEB |
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lysosomal Ca2+ release through MCOLN1 activates PPP3CA, which binds and dephosphorylates & |
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8203;TFEB, thus promoting its nuclear translocation |
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KDM7A mediates TNF-induced ICAM1 protein upregulation mediated by induction of KDM7A, which regulates the TFEB-mediated lysosomal activity |
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STUB1, a chaperone-dependent E3 ubiquitin ligase, modulates TFEB activity by preferentially targeting inactive phosphorylated TFEB for degradation by the ubiquitin-proteasome pathway |
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TFEB nucleo-cytoplasmic shuttling suggest an unpredicted role of MTOR in nuclear export |
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TFEB-mediated endocytosis is a critical process leading to activation of MTOR and autophagic function, thus identifying the importance of the dynamic endolysosomal system in cellular clearance |
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KAT2A is a specific TFEB acetyltransferase, and acetylation by KAT2A results in the decrease in TFEB transcriptional activity |
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PDCD4, a tumor suppressor, decreased levels of nuclear TFEB to inhibit lysosome biogenesis and function |
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MTOR specifically controls TFEB and TFE3 cytosolic retention, whereas AMPK is essential for TFEB and TFE3 transcriptional activity |
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novel function of GABARAPL1 to activate TFEB, a master transcription factor of autophagy and lysosome function during lysosomal damage |