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FLASH GENE
Symbol EIF3C contributors: mct - updated : 19-02-2019
HGNC name eukaryotic translation initiation factor 3, subunit C
HGNC id 3279
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue  highly
Lymphoid/Immunethymus   highly
Reproductivemale systemtestis  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a PCI (PINT) proteasome int-6, Nip-1, Trip-15, motif
  • HOMOLOGY
    interspecies homolog to S.cerevisiae protein Nip-1
    Homologene
    FAMILY eukaryotic translation initiation factor family
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    basic FUNCTION
  • eukaryotic translation initiation factor, stabilizing initiator Met tRNA (TRIMs) binding to 40S subunits
  • promoting the association of Met-tRNA and mRNA
  • vital to translation initiation, as its downregulation decreases the global protein synthesis and causes a polysome run-off
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the EIF3 multiprotein complex, 600kDa
  • INTERACTION
    DNA
    RNA binding to the 40S ribosome
    small molecule
    protein
  • schwannomin interacting protein (most effective activity for inhibiting cellular proliferation when EIF3C
  • was highly expressed)
  • interacting with EIF3K
  • EIF5-CTD interacts directly with the translation initiation factors EIF1, EIF2S2, and EIF3C, thus forming together with EIF2S2 bound Met-tRNA(i)(Met) the multifactor complex (MFC)
  • dimer of subunits EIF3A and EIF3C serves as a central scaffold to which most of the other subunits bind
  • EIF4G1 protein binds to EIF3C, EIF3D, and EIF3D to promote mRNA recruitment to the ribosome
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in meningiomas, that had lost schwannomin expression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target target for treatment of NF2 patient tumors
    ANIMAL & CELL MODELS