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FLASH GENE

Symbol

SLC35A3

contributors: mct - updated : 09-04-2014

HGNC name	solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
HGNC id	11023

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon   highly   liver       highly Reproductive female system uterus     highly Urinary kidney       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

homolog to C.elegans c03h5.2

intraspecies

homolog to UDP-GALand CMP-sialic acid transporter

Homologene

FAMILY	solute carrier family 35
	nucleotide sugar transporter family

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi

basic FUNCTION	involved in nucleotide sugar transport in the Golgi apparatus
	biological function of SLC35A2 and SLC35A3 in galactosylation of macromolecules may be coupled
	SLC35A2 and SLC35A3 function in glycosylation is combined via their mutual interaction
	regulates biosynthesis of highly branched N-glycans and keratan sulfate
	major Golgi uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) transporter 9)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

carbohydrate

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

SLC35A2 and SLC35A3 cooperate in the UDP-Gal delivery for glycosyltransferases located in the Golgi apparatus

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

AMRS

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS