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FLASH GENE
Symbol CD163 contributors: mct - updated : 26-01-2016
HGNC name CD163 molecule
HGNC id 1631
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemplacenta  highly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticmonocyte Homo sapiens
Lymphoid/Immunemacrophage Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text stem cells progenitor cells
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a leader peptide (40AA)
  • an extra cellular domain of 1003 residues containing nine long type scavenger receptor cysteine-rich (SRCR) domains, with SRCR domain 3 that is an exposed domain and a critical determinant for the calcium-sensitive coupling of haptoglobin
  • a transmembrane segment of 24 residues
  • a cytoplasmic domain of 49 AA
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • scavenger receptor cystein-rich (SRCR) superfamily
  • class B subfamily
  • CATEGORY antigen , receptor membrane
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • involved in myeloid specific gene expression, signal inducing
  • activation of CD163 on hematopoietic progenitor cells may mediate a stimulatory effect on erythropoiesis
  • adhesion receptor for erythroblasts in erythroblastic islands, and may have a regulatory role during erythropoiesis
  • macrophage receptor for endocytosis of haptoglobin
  • scavenger receptor pathway involved in detoxification and clearance of extracellular hemoglobin (Hb)
  • acting as a receptor for hemoglobin-haptoglobin complexes and to mediate cell-cell interactions between macrophages and developing erythroblasts in erythroblastic islands
  • macrophage receptor for bacteria and during bacterial infection, on resident tissue macrophages acts as an innate immune sensor and inducer of local inflammation
  • soluble form of human CD163 is released from the cell surface by proteolysis after oxidative stress or inflammatory stimuli
  • scavenger receptor for haptoglobin-hemoglobin complexes, that is shedded (as sCD163) by inflammatory stimuli
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule other,
  • bind both Gram-positive and -negative bacteria, and a previously identified cell-binding motif in the second scavenger domain of CD163 was sufficient to mediate this binding
  • protein
  • PF4 may promote atherogenesis by suppressing CD163 in macrophages, which are then unable to upregulate the atheroprotective enzyme heme oxygenase-1 in response to hemoglobin
  • ADAM17 mediates ectodomain shedding of the scavenger receptor CD163
  • overexpression of CD163 by macrophages may be involved in the development of preretinal fibrovascular membranes (FVMs)in eyes with proliferative diabetic retinopathy (PDR), partly through periostin production
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in acute liver failure significantly correlated with fatal outcome and might be used with other parameters to determine prognosis
    constitutional     --over  
    during the hemorrhagic fever with renal syndrome acute phase were significantly higher in patients than during the convalescent stage and the levels in the healthy controls
    constitutional     --over  
    in monocytes of active Crohn disease (CD) or ulcerative colitis (UC), associated with increased macrophage activation
    constitutional     --over  
    in people with diabetic polyneuropathy, suggesting that inflammation plays a role in the development of neural impairment
    constitutional     --over  
    in gestational diabetes mellitus
    tumoral     --over  
    associated with poor prognosis in patients with ovarian cancer
    constitutional     --over  
    association of elevated sCD163 with organ dysfunction and adverse outcome of critical illness
    constitutional     --over  
    in patients with scleroderma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • soluble CD163 may be a potential biomarker for the severity of diabetic polyneuropathy
  • soluble CD163 values were significantly higher in bone marrow samples than in the matched blood samples, and is a a novel biomarker in multiple myeloma
  • may have a role as a biomarker of rheumatoid arthritis (RA) activity suggesting that resident macrophages are important for joint destruction
  • Therapy target
    ANIMAL & CELL MODELS