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FLASH GENE
Symbol SLC18A2 contributors: mct - updated : 01-02-2011
HGNC name solute carrier family 18 (vesicular monoamine), member 2
HGNC id 10935
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland   highly
 pancreas   highly Homo sapiens
 thyroid   highly
Nervousbrainmidbrain    Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Endocrineislet cell (alpha,beta...) Homo sapiens
Nervousneuron Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • twelve transmembrane spanning segments (12TM)
  • HOMOLOGY
    interspecies homolog to murine Slc18a2
    Homologene
    FAMILY
  • major facilitator superfamily
  • vesicular transporter family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    text vesicular membrane
    basic FUNCTION
  • involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters
  • essential for loading monoamines into vesicles and maintaining normal neurotransmission
  • regulates neurotransmission and reduces cytosolic toxicity of monoamines
  • sequesters cytoplasmic dopamine into synaptic vesicles for storage and release
  • during the stimulus, the endocytosis of VMAT2 (but not VGLUT1) accelerates dramatically in midbrain dopamine but not hippocampal neurons, indicating a novel, cell-specific mechanism to sustain high rates of release
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • direct binding between the N-terminus and the third cytoplasmic loop of SLC18A2, as well as, a region containing the substrate binding and the C-terminal domains of HSPA8
  • cell & other
    REGULATION
    inhibited by fluoxetine (inhibited the activity of SLC18A2 by a mechanism different from that of reserpine and did not directly interact with the active site of SLC18A2
    Other regulated by HSPA8 (important role for HSPA8 in SLC18A2 function and regulation)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in platelets from patients with Parkinson disease
    constitutional     --over  
    might be a compensatory mechanism to restore and maintain synaptic transmission in dopaminergic midbrain neurons during nicotine withdrawal
    tumoral     --low  
    silencing by DNA hypermethylation and/or allelic loss is a frequent event in prostate cancer and a novel independent predictor of biochemical recurrence after prostatectomy
    Susceptibility
  • to alcoholism
  • to Parkinson disease
  • to schizophrenia and bipolar disorder
  • Variant & Polymorphism SNP
  • 14234G>A and 2504T>C decreasing the risk of alcoholism
  • protective role for gain-of -function haplotypes in sporadic Parkinson disease, through increasing of sequestration of dopamine in secretory vesicles
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS