SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,mitochondria,inner
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| intracellular,cytoplasm,organelle,membrane
|
| intracellular,cytoplasm,organelle,endoplasmic reticulum
|
text
| in the inner mitochondrial membrane |
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reside in the ER membrane |
basic FUNCTION
| may be involved in Ca(2+) signaling and/or homeostasis |
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playing a role in mitochondrial morphology |
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encoding factors involved in both K+ homeostasis and organelle volume control |
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regulates the volume of the mitochondrial matrix |
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binding partner for THEM4 that may play an important role in mitochondrial fragmentation via OPA1-cleavage |
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serves as an anchor protein for complex formation with the mitochondrial ribosome and regulates mitochondrial biogenesis |
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plays an essential role in mitochondrial K+ homeostasis by mediating the mitochondrial K+/H+ exchange that is of prime importance for organelle-volume control |
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acts as an anchor protein and associates with mitochondrial ribosome protein L36 |
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served as an anchor protein for complex formation between mitochondria and ribosome, and regulated mitochondrial biogenesis |
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mitochondrial Ca2+/H+ antiporter that achieved mitochondrial Ca2+ sequestration at small Ca2+ increases |
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LETM1 and UCP2/3 independently contribute to two distinct, mitochondrial Ca2+ uptake pathways in intact endothelial cells |
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its activity is essential for ER Ca(2+) uptake |
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SLC8B1 but not LETM1, mediates Ca(2+) extrusion from mitochondria |
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role of LETM1-dependent mitochondrial Ca(2+) flux in shaping cellular bioenergetics |
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LETM1 is a Ca2+/H+ antiporter and most likely responsible for mitochondrial Ca2+ output |
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key role of LETM1 in monovalent cation homeostasis, suggesting that the effects of its modulation on mitochondrial transmembrane Ca2+ fluxes may reflect those on Na+/H+ exchange activity |
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LETM1 governs the mitochondrion ion channel and is involved in mitochondrial respiration |
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remarkable role of LETM1 in mitochondrial network physiology and in mitochondrion& |
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8209;mediated cell death |
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LETM1 plays likely a fundamental role in the organization of mitochondrial membrane morphology |
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encodes an inner mitochondrial membrane protein with an osmoregulatory function controlling mitochondrial volume and ion homeostasis |
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LETM1 function is required for the maintenance of mitochondrial cationic and osmotic balance |