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FLASH GENE
Symbol NSA2 contributors: mct - updated : 21-04-2010
HGNC name NSA2 ribosome biogenesis homolog (S. cerevisiae)
HGNC id 30728
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  moderately Homo sapiens
Lymphoid/Immunethymus   highly Homo sapiens
Reproductivefemale systemplacenta  highly Homo sapiens
 male systemprostate  moderately Homo sapiens
Respiratorylung   moderately Homo sapiens
Urinarykidney   highly Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two nuclear localization signals (NLSs), also overlapped with nucleolar localization signals (NOLSs),implicated in the nucleolar targeting of NSA2
  • HOMOLOGY
    interspecies ortholog to rattus Cdk105
    Homologene
    FAMILY
  • ribosomal protein S8e family
  • CATEGORY RNA associated , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleolus
    text located in the nucleolus of cells
    basic FUNCTION
  • being essential for the large ribosomal subunit biogenesis
  • nucleolar protein involved in cell proliferation and cell cycle regulation
  • may act as a cell cycle repressor and plays a role in cell proliferation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • functional partner of the putative GTPase GTPBP4
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    in hairy-cell leukemia
    constitutional     --over  
    promoted cell growth in different cell lines and regulated the G1/S transition in the cell cycle
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS