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FLASH GENE
Symbol NUP160 contributors: mct/pgu - updated : 29-05- 201
HGNC name nucleoporin 160kDa
HGNC id 18017
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Nervousbrain    
Reproductivemale systemprostate   
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone   
Muscularstriatumcardiac  
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
intracellular,nucleus
intracellular,nuclear envelope,pore
text close to the nuclear envelope
basic FUNCTION
  • histidine acid phosphatase, binding proteins to the nuclear pore complex
  • NUP107-160 complex is dynamic in mitosis and promotes spindle assembly in a manner that is distinct from its functions at interphase nuclear pores
  • NUP107-160 subcomplex is stable throughout the cell cycle, and phosphorylation does not affect interactions within the NUP107-160 subcomplex, but regulates the association of the subcomplex with the NPC and other proteins
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport , cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • NUP107-160 complex interacts with CENPF, but CENPF only moderately contributes to its targeting to kinetochores
  • KPNB1 forms a high-molecular-weight complex with both AHCTF1 and the NUP107-160 complex in cytosol
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NUP107-160 interacts with the gamma-tubulin ring complex (gamma-TuRC), an essential and conserved microtubule nucleator, and recruits gamma-TuRC to unattached kinetochores
  • N terminus of POM121 directly binds the beta-propeller regions of NUP155 and NUP160
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --other  
    alterations in specific proteins (NDC1, NUP160, NUP153 and NUP93) in ischaemic and dilated human heart
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS