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FLASH GENE
Symbol NCOA6 contributors: mct/pgu - updated : 12-01-2017
HGNC name nuclear receptor coactivator 6
HGNC id 15936
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemovary  highly
 male systemtestis  highly
 male systemprostate  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES acid
STRUCTURE
motifs/domains
  • N terminal acidic domain
  • two NR box domain with specific LXXLL sequence motif, a short hydrophobic domain that is sufficient for ligand-dependent interactions with nuclear receptors
  • two glutamine-rich domains
  • an intrinsic glutamine-rich activation domain
  • multiple functional modules including pleckstrin homology and C2 domains, inhibited exocytosis, probably via the binding to membrane phosphoinositides through the pleckstrin homology domain
  • C-terminal domain is required for the interaction with SMAD2, and SMAD3
  • HOMOLOGY
    Homologene
    FAMILY nuclear receptor coactivator family
    CATEGORY regulatory , transcription factor , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • coactivator of PPARG and RXR alpha (potentiates the transcriptional activities)
  • playing a critical role as a coactivator of nuclear receptors
  • coactivator of the xenobiotic nuclear receptor NR1I3 and mediate the specific xenobiotic response by NR1I3
  • coactivator of multiple nuclear receptors and transcription factors
  • with MLL3, NCOA6 and MLL4 are recruited to FXR target genes in a ligand-dependent manner
  • co-activator for nuclear hormone receptors and certain other transcription factors
  • plays an important role in embryonic development, adipocyte differentiation, metabolism and breast carcinogenesis
  • controls E(2) sensitivity and uterine receptivity by regulating multiple E(2)-signaling components
  • has an inhibitory role in regulated exocytosis
  • is a transcriptional coactivator and crucial for insulin secretion and glucose metabolism in pancreatic beta-cells
  • NCOA6 stimulates insulin secretion likely, at least partially, by modulating NAMPT expression in pancreatic beta-cells
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    text transcriptional activator
    PATHWAY
    metabolism
    signaling hormonal
    a component
  • component of a steady-state complex (ASCOM) also containing retinoblastoma binding protein RBQ3, alpha/beta tubulins and a subset of trithorax group proteins
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • thyroid hormone receptor binding
  • peroxisome proliferation-activated receptor interacting protein
  • CREBBP
  • interacting with ATF2 to induce target gene transcription during granulocytic differentiation
  • interacting with ZNF335
  • binds to many nuclear receptors in a ligand-dependent manner through its two LxxLL motifs
  • differentially regulates CYP2C9 and CYP3A4 gene expression though both the genes are regulated by the same nuclear receptors
  • reported coactivator for ESR1, attenuates E(2) sensitivity to determine uterine receptivity to embryo implantation under normal physiological conditions
  • cell & other
    REGULATION
    activated by TGS1
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification    
    in breast cancer
    constitutional       loss of function
    in Dilated cardiomyopathy (DCM) (
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • PRIP-deficient mice showed increased serum gonadotropins, but decreased gonadal steroid hormones
  • Prip gene knock-out (KO) in mice increases bone formation and concomitantly decreases bone resorption, resulting in increased bone mineral density and trabecular bone volume