protein
| binds the late-acting ESCRT proteins Did2p/charged MVB protein (CHMP) 1 and VPS4A, VPS4B and exhibits synthetic vacuolar protein sorting defects when combined with mutations in the VTA1/CHMP5 complex |
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IST1 interaction is important for spartin recruitment to the midbody and that spartin participates in cytokinesis |
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CHMP1B and IST1 directly interacted with a tandem repeat of MIT domains of CAPN7 and autolytic activity of CAPN7 was enhanced by IST1 |
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strong interactions of MITD1 with CHMP1B, CHMP2A, and IST1 |
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role of MITD1 in negatively regulating the interaction of IST1 with VPS4A |
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a tandem MIT domain of VTA1, can bind MIM elements within both CHMP1A and IST1, implying that the complexes probably interact directly in cells |
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efficient abscission during cytokinesis requires proper function of the ESCRT-III protein IST1, which binds to the microtubule interacting and trafficking (MIT) domains of VPS4A, VTA1, and SPART via its C-terminal MIT-interacting motif (MIM) |