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FLASH GENE
Symbol KANK1 contributors: mct/npt - updated : 13-12-2017
HGNC name KN motif and ankyrin repeat domains 1
HGNC id 19309
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Respiratoryrespiratory tractlarynx  highly
Skin/Tegumentskin   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
IMPRINTING maternally
text in familial cerebral palsy
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • conserved motif at the N-terminal (KN motif) containing potential motifs for nuclear localization and export signals (Zhu 2008)
  • four ankyrin repeat domains in its C-terminus
  • an ankyrin-repeat domain interacts with the third and fourth coiled-coil domains of KIF21A (Kakinuma 2009)
  • HOMOLOGY
    Homologene
    FAMILY
  • KANK family
  • CATEGORY storage , structural protein
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    text predominantly occurring in the cytosolic fraction, while KIF21A slightly enhanced the translocation of KANK1 to the membrane fraction (Kakinuma 2009)
    basic FUNCTION
  • ankyrin repeat domain-containing protein which regulates actin polymerization
  • suggesting a role in tumorigenesis of renal cell carcinoma
  • all of these family proteins have an identical role in the formation of actin stress fibers (Zhu 2008)
  • inhibited the activation of RhoA through PI3K/Akt/14-3-3 signaling (Kakinuma 2009)
  • negatively regulates the formation of lamellipodia by inhibiting the interaction between Rac1 and BAIAP2) (Roy 2009)
  • effects of ARFGEF1 and KANK1 proteins on cell polarity and directed migration during wound healing
  • KANK1, KANK2, KANK3, KANK4 were co-opted for vertebrate vascular development
  • scaffolding molecule in controlling microtubule growth at the cell periphery
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction with KIF21A (Kakinuma 2009)
  • KANK1 has multiple actions in cells and also interacts with KIF21A
  • could recruit kinesin family member 21A (KIF21A) to the cell cortex to control microtubule growth via its C-terminal ankyrin domain
  • a stretch of ~22 amino acids in KIF21A is sufficient for binding to KANK1 and its close homolog KANK2, and solved the complex structure of the KIF21A peptide with either the KANK1 ankyrin domain or the KANK2 ankyrin domain
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) FCPAL
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target could be a therapeutic target in FEOM1 (Kakinuma 2009)
    ANIMAL & CELL MODELS