basic FUNCTION
| controls passage of membrane proteins across the nuclear pore complex |
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associated with cellular functions, including ciliogenesis, chromatin organization, transcriptional regulation, and chromosome segregation |
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in NUP188-depleted mitotic cells, chromosomes fail to align to the metaphase plate, which causes mitotic arrest due to the spindle assembly checkpoint |
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NUP188 promotes chromosome alignment through K-fiber formation and recruitment of NUMA1 to spindle poles |
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nucleoporin NUP93 assisted by its interactors NUP188 and NUP205 mediates the repression of HOXA gene expression |
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potential role of NUP188 in dendritic development |