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FLASH GENE
Symbol NUDT6 contributors: mct - updated : 09-02-2018
HGNC name nudix (nucleoside diphosphate linked moiety X)-type motif 6
HGNC id 8053
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousnerve   highly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immuneactivated B lymphocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a Nudt/MuT (Nudix)domai
  • an atypical nuclear localization signal (NLS)
  • HOMOLOGY
    interspecies homolog to murine cleaning gene
    Homologene
    FAMILY Nudix family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • potentially regulator of FGF2 expression whose function is to cleanse the cell of potentially deleterious endogenous metabolites and to modulate the accumulation of intermediates in biochemical pathways
  • potential central role for the FGF2/NUDT6 antisense transcript in the ovarian follicle assembly process
  • histone acetylation and additional chromatin modifiers are important in determining the relative levels of FGF2 and NUDT6, supporting a model in which epigenetic remodeling contributes to their relative expression levels
  • FGF2 and NUDT6 in the regulation of cell transformation and cell cycle progression
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS detoxification
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • FGF2 is regulated endogenously by an overlapping antisense gene called Nudix-type motif 6 (NUDT6)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS