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FLASH GENE
Symbol NUDT3 contributors: - updated : 02-11-2006
HGNC name nudix (nucleoside diphosphate linked moiety X)-type motif 3
HGNC id 8050
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver    
Endocrinepancreas    
Nervousbrain   predominantly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • MuT domain, metabolizing some nucleoside phosphates that may play a role in signal transduction
  • also putatively involved in dephosphorylation of 8-oxo-dGTP which causes AT to GT transversion mutations
  • HOMOLOGY
    interspecies homolog to murine cleaning gene putative
    Homologene
    FAMILY
  • Nudix hydrolase family
  • DIPP subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • diphosphoinositol polyphosphate phosphohydrolase whose function is to cleanse the cell of potentially deleterious endogenous metabolites and to modulate the accumulation of intermediates in biochemical pathways in mouse
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS detoxification
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    Mg2+
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS