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FLASH GENE
Symbol YWHAQ contributors: mct/npt - updated : 11-01-2021
HGNC name tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
HGNC id 12854
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas   highly
 thyroid   highly
Lymphoid/Immunelymph node   highly
Urinarybladder   highly
Visualeyeanterior segmentcornea  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
Connectivebone  highly
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentkeratinocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , dimer
HOMOLOGY
Homologene
FAMILY
  • 14.3.3 family
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • inhibitor of apoptosis through inhibiting the activation of p38 MAP kinase
  • multifunctional regulator
  • forms a molecular complex with HSPD1 and PRNP in the CNS under physiological conditions and this complex might become disintegrated in the pathologic process of prion diseases
  • participation of YWHAQ in the regulation of the placental epigenome that may participate in the molecular mechanisms that govern the pathological process of preeclampsia
  • CELLULAR PROCESS cell life, cell death/apoptosis
    cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • p38 MAP kinase
  • interaction between CENPJ and 14-3-3, and this interaction appears to be phosphorylation and cell cycle dependent
  • binds SRPK2, which is regulated by Akt phosphorylation, and Akt phosphorylation also provokes SRPK2 nuclear translocation that is blocked by YWHAQ (Jang 2009)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast lesion patients as compared with normal controls
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • differential expression of YWHAH, YWHAQ throughout brain regions of rats with insulin resistance