SUBCELLULAR LOCALIZATION
| intracellular
|
| intracellular,cytoplasm,cytosolic
|
| intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
|
| intracellular,nucleus,nucleoplasm
|
| intracellular,nucleus,nucleolus
|
| intracellular,nuclear envelope
|
text
| localized to interphase nucleus and mitotic chromosomes |
|
in interphase cells, SPIN1 specifically localizes to the nucleoli, and localizes to the active ribosomal DNA (rDNA) repeats, facilitating the expression of rRNA genes 6) |
basic FUNCTION
| playing a role in cell-cycle regulation during the transition from gamete to embryo |
|
important gene for mitotic chromosome functions, and its disrupted regulation results in abnormal cell division, a mechanism that may be involved in tumorigenesis |
|
meiotic spindle-binding protein, involved in gametogenesis |
|
target for cell cycle-dependent phosphorylation and disturb the cell cycle |
|
is an important gene for mammalian mitotic chromosome functions, and disrupted regulation results in abnormal cell division, a mechanism that may be involved in tumorigenesis |
|
meiotic spindle-associated protein |
|
is a histone methylation effector protein that specifically recognizes H3K4 methylation |
|
involved in the process of spindle organization and chromosomal stability and plays a role in the development of cancer |
|
regulates maternal transcripts post-transcriptionally and is involved in meiotic resumption |
|
histone effector that senses a cis-tail histone H3 methylation pattern involving trimethyllysine 4 (H3K4me3) and asymmetric dimethylarginine 8 (H3R8me2a) marks |
|
is a transcriptional coactivator with critical functions in embryonic development and emerging roles in cancer |
|
regulates gene expression in the Wnt signaling pathway by directly interacting with transcription factor 4 (TCF4) |
|
histone code reader SPIN1 controls skeletal muscle development |