basic FUNCTION
| required for activation of UBL1 |
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acting as a UBL1 E1 ligase for SUMO1, SUMO2, SUMO3 and probably SUMO4 |
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mediating ATP-dependent activation of UBL1 and formation of a thiolester with a conserved cysteine residue on UBA2 |
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acting as an enzyme activator |
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could potentially be used to antagonize Vif-mediated APOBEC3G degradation by preventing polyubiquitination and thus inhibits HIV-1 replication (Li 2008) |
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demonstrated to serve an essential role in the proliferation of colorectal cancer |
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plays a vital role in gastric cancer cell migration and invasion, possibly by regulating the WNT/CTNNB1 signaling pathway and epithelial-mesenchymal transition (EMT) |
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basic component of E1-activating enzyme in the SUMOylation system |
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was a critical cell cycle and proliferation regulator |