Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PRSS21 contributors: SGE - updated : 30-04-2010
HGNC name protease, serine, 21 (testisin)
HGNC id 9485
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas    
Lymphoid/Immunespleen    
Reproductivefemale systemuteruscervix  
 female systemovary   
 male systemtestis  highly
 male systemprostate   
Respiratorylung    
 respiratory tractlarynx   
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticeosinophil
Reproductivespermatocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • membrane type serine-proteinase
  • a signal peptide
  • a catalytic domain
  • a C terminal hydrophobic extension (anchor)
  • conjugated GlycoP , LipoP
    HOMOLOGY
    Homologene
    FAMILY
  • trypsin family of serine proteases
  • CATEGORY enzyme , tumor suppressor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • localized on the surface of cultured tumor cells as a glycosyl-phosphatidylinositol-linked protein
  • localized at plasma membrane of premeiotic testicular germ cells
  • basic FUNCTION
  • regulating proteolytic events associated with testicular germ cell maturation
  • may be involved in progression of testicular tumors of germ cell origin
  • can promote cellular processes that drive malignant transformation
  • may promote carcinogenesis by inhibiting tumor suppressor activity of SERPINB5 )
  • may be active on peptide linkages involving the carboxyl gp of lysine or arginine
  • proteolytic factor that directs epididymal sperm cell maturation and sperm-fertilizing ability
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SERPINB5
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in ovarian cancer
    tumoral     --low  
    in testicular tumors (role in progression of testicular tumor of germ cell origin)
    Susceptibility
    Variant & Polymorphism
    Candidate gene aberrant regulation of PRSS21 may underlie certain secondary male infertility syndrome, such as "easily decapited spermatozoa"
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    target for therapeutic intervention in cancer
    ANIMAL & CELL MODELS