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FLASH GENE
Symbol SYCP2 contributors: mct/npt - updated : 14-01-2020
HGNC name synaptonemal complex protein 2
HGNC id 11490
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivestomach   highly
Endocrineneuroendocrinepituitary  highly
Reproductivefemale systembreastmammary gland highly
 male systemtestis  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 14S/T-P and 36S/T-S/T motifs putatively involved in DNA binding
  • two potential p34cdc2 (CDC2) target sites
  • two nuclear localization signals (NLS)
  • multiple potential DNA binding motifs
  • a C terminal potential coiled-coil structure, interacting with SYCP3
  • HOMOLOGY
    interspecies homolog to murine Scp2
    intraspecies paralog to SYCP2L
    Homologene
    FAMILY
  • SYCP2 family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in the structural organization of meiotic prophase chromosomes
  • required for cohesin core integrity at diplotene but not for centromere cohesion at the first meiotic division
  • acts as a linker between SYCP1 and SYCP3 and therefore would be the missing connecting link between lateral elements and transverse filaments essential for proper chromosome synapsis (Winkel 2009)
  • SYCP2 may act as a bridge that brings the Synaptonemal complex and centromere together
  • SYCP3 and the SYCP2 C terminus, form a compact core around which cohesin complexes, HORMADs, HORMAD1, and HORMAD2 and the N terminus of SYCP2 are arrayed
  • role of SYCP2 in human male fertility
  • CELLULAR PROCESS cell cycle
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of synaptonemal complex protein 2, axial element
  • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • SYCP2 interacting with SCYP3 (associate with the centromere regions of male, but not female, metaphase-I chromosomes, suggesting a sex-specific function for the two proteins)
  • SYCP2 N-reminal region interacts with the centromere during meiosis I, with CENPJ and CENPF
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPGF41
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice lacking the Sycp2 coiled-coil domain also have an infertility phenotype