Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ZRANB2 contributors: mct/npt/pgu - updated : 25-05-2011
HGNC name zinc finger, RAN-binding domain containing 2
HGNC id 13058
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Lymphoid/Immunethymus   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Muscularstriatumskeletal highly
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticmonocyte
Lymphoid/Immunemacrophage
cell lineage
cell lines monoblast cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two RanBP2-type zinc fingers (ZnF), binding to a single AGGUAA motif and the 2 domains combine to recognize AGGUAA(Nx)AGGUAA double sites (Loughlin 2009), containing four highly conserved cysteine residues, and forming a stable, monomeric structure
  • a nuclear localization signal (NLS)
  • Asp-Glu and a Ser-Arg rich regions, arginine/serine-rich (RS) domains
  • a zinc coordinating DNA binding domain
  • conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY
  • zinc finger protein family
  • ZRANB2 family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • potential regulator of transcription and/or splicing
  • involved in the regulation of cell morphogenesis or cell identity
  • splice factor required for alternative splicing of SFRS10/TRA2B transcripts
  • can regulate alternative splicing but lacks canonical RNA-binding domains
  • might act by binding directly to a subset of 5prime splice sites so as to prevent recognition of those sites by the spliceosome
  • CELLULAR PROCESS nucleotide, transcription, maturation
    nucleotide, transcription, regulation
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS development
    text hematopoiesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • binds to mRNA, as well as the essential splicing factors SNRNP70 and U2AF1 and the novel splicing component AKAP17A
  • interacts with the spliceosomal proteins SNRNP70, and U2AF1 (can acts early in the splicing reaction, consistent with a role in splice site choice)
  • RanBP2-type zinc finger (ZnF) domains from ZRANB2 can bind to a sequence containing the consensus AGGUAA
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS