protein
| activating interleukin 1 beta |
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mediator of RIPK2 cleavage in hypoxia/ischemia -stimulated neurons |
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physically interacted with full length RARRES3 (enzymatic activity of caspase-1 was necessary to control RARRES3, although it was not a substrate of proteolytic cleavage by caspase-1) |
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interacting with PANX1 |
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AIM2 is a new receptor for cytoplasmic DNA, which forms an inflammasome with the ligand and PYCARD to activate CASP1 |
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interaction with TIRAP (inhibitory, rather than an activating role for CASP1 in TIRAP regulation, and the caspase-1 cleavage site in TIRAP is part of a TIR-domain interaction site) |
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interacting with PYCARD, AIM2 and NLRP3 (PYCARD inflammasomes, including AIM2 and NLRP3, are critical for CASP1 activation induced by S. pneumoniae) |
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important role of CASP4 in inflammation and innate immunity through activation of CASP1 |
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NLRP3 is a key component of one of several distinct cytoplasmic multiprotein complexes (inflammasomes) that mediate the maturation of the proinflammatory cytokine IL1B by activating CASP1 |
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LRRFIP2 enhances the interaction between FLII and CASP1, facilitating the inhibitory effect of FLII on CASP1 activation |
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PLIN2 inhibits insulin& |
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8209;induced glucose uptake by activating NLRP3, CASP1 and IL1B, leading to a decreased IRS1 expression |
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RAB39A binds CASP1 and is required for CASP1-dependent interleukin-1beta secretion |
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CASP1, controls pyroptosis- and ubiquitin-independent proteasomal degradation of UBE2L3 upon canonical and non-canonical inflammasome activation by sterile danger signals and bacterial infection |
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epigenetic regulation of NOS2 by CASP1 involves cleavage of the chromatin regulator PARP1 and chromatin accessibility of the NFKB1 binding sites located at the NOS2 promoter |
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endogenous NLRC3 interacts with both PYCARD and pro-caspase-1 but not with NLRP3, disrupts PYCARD speck formation through its CARD, and impairs the PYCARD and pro-caspase-1 interaction |
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CASP4 physically interacts with CASP1 and is believed to be a proinflammatory caspase that can induce the inflammatory form of programmed cell death (pyroptosis) and the release of mature interleukin IL1B |
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