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FLASH GENE
Symbol PMVK contributors: mlc - updated : 24-10-2007
HGNC name phosphomevalonate kinase
HGNC id 9141
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
Endocrinepancreas   highly
Lymphoid/Immunelymph node   highly
Skin/Tegumentskin   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal peroxisomal targeting sequence (PTS2)
  • a C terminal PTS1 sequence
  • mono polymer monomer
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,peroxisome
    basic FUNCTION
  • phosphomevalonate kinase ATP dependent
  • converting melanovate 5-P into M5-PP in the pathway for the synthesis of cholesterol and isoprenoids (minor role of peroxisomes in isoprenoid biosynthesis)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component a structural constituent of membranes and precursor for bile acids and steroid hormones
    INTERACTION
    DNA
    RNA
    small molecule other,
    protein
    cell & other
    REGULATION
    induced by sterol
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS