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FLASH GENE

Symbol

ZNF263

contributors: SGE/npt - updated : 04-05-2009

HGNC name	zinc finger protein 263
HGNC id	13056

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen           thymus       highly Cardiovascular heart         Digestive intestine small intestine         intestine large intestine colon       liver         Endocrine pancreas         Nervous brain         Reproductive female system ovary         male system prostate         male system testis       Respiratory lung         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic         Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Lymphoid         Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal, pregnancy

Text	placenta, tissues

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal SCAN box leucine-rich mediating self-association and oligomerization
	a finger-associated structural motif
	the A element of the Krüppel-associated box (KRAB)
	nine zinc finger motifs C2H2 (Krüppel) type

secondary structure

two alpha helices

conjugated

MetalloP

HOMOLOGY

interspecies	homolog to murine Zfp263
	homolog to C.elegans F42G4.3A

Homologene

FAMILY	krueppel C2H2-type zinc-finger protein family
	SCAN subfamily

CATEGORY

regulatory , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION

can have both positive and negative effects on transcriptional regulation of its target genes (Frietze 2010)

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule	metal binding,
	Zn2+

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS