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FLASH GENE
Symbol ZNF263 contributors: SGE/npt - updated : 04-05-2009
HGNC name zinc finger protein 263
HGNC id 13056
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
 thymus   highly
Cardiovascularheart    
Digestiveintestinesmall intestine   
 intestinelarge intestinecolon  
 liver    
Endocrinepancreas    
Nervousbrain    
Reproductivefemale systemovary   
 male systemprostate   
 male systemtestis   
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Lymphoid    
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text placenta, tissues
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal SCAN box leucine-rich mediating self-association and oligomerization
  • a finger-associated structural motif
  • the A element of the Krüppel-associated box (KRAB)
  • nine zinc finger motifs C2H2 (Krüppel) type
  • secondary structure two alpha helices
    conjugated MetalloP
    HOMOLOGY
    interspecies homolog to murine Zfp263
    homolog to C.elegans F42G4.3A
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
  • SCAN subfamily
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • can have both positive and negative effects on transcriptional regulation of its target genes (Frietze 2010)
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS