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FLASH GENE
Symbol PDE9A contributors: mct - updated : 18/10/2008
HGNC name phosphodiesterase 9A
HGNC id 8795
EXPRESSION
Rna function mRNA expressed in all cortical areas studied (insular cortex, entorhinal cortex and visual cortex), and in putamen
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
Cardiovascularheart    
Digestiveintestinelarge intestinecolon highly
Nervousbrainhindbraincerebellumcerebellar cortex  Homo sapiens
 nerve   highly Homo sapiens
Reproductivemale systemprostate  highly
Urinarykidney    
cells
SystemCellPubmedSpeciesStageRna symbol
NervousPurkinje cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text placenta, kidney
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal regulatory domain
  • a C terminal catalytic domain
  • two putative divalent metal sites
  • HOMOLOGY
    Homologene
    FAMILY
  • cyclic nucleotide phosphodiesterase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nuclear envelope
    basic FUNCTION
  • metal ion-dependent enzymes that regulate cellular signaling by metabolic inactivation of the ubiquitous second messengers cAMP and cGMP
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Mn2+ or Mg2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    significantly higher in the reticulocytes and neutrophils of sickle cell disease individuals, compared to control cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target since elevation of haematopoietic intracellular cGMP may be beneficial in SCD (sickle cell disease), the relatively limited tissue distribution of PDE9A suggests that it could represent a novel drug target for SCD
    ANIMAL & CELL MODELS