protein
| FLI binding |
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interacts with DVL3 to increase the cellular levels of beta-catenin and activate beta-catenin/LEF/TCF-dependent transcriptional activity |
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MYD88 interacting with LRRFIP2 and LRRFIP1, and both are positive regulators of NF-kappaB activity |
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binds to MYD88 through its serine-rich domain (phosphorylation at serine 202 was found to regulate the dynamics of the LRRFIP2-MYD88 interaction, which in turn modulated the strength and duration of TLR4 signaling) |
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LRRFIP2 is involved in NFKB1 activation following stimulation of TLR4 |
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LRRFIP2 and TOR1AIP2 are FATylation substrates |
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LRRFIP2 enhances the interaction between FLII and CASP1, facilitating the inhibitory effect of FLII on CASP1 activation |
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FLII is recruited to the NLRP3 inflammasome by leucine-rich repeat FliI-interaction protein 2 (LRRFIP2), an NLRP3-associated protein |
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LRRFIP2 and FLII is required for the co-localization of the NLRP3 and F-actin as well as for the inhibition of NLRP3 inflammasome activity |
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LRRFIP2 is regulated by epithelial splicing regulatory protein 1 (ESRP1) and this is correlated with metastatic potential of gastric cancer cells |
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epithelial LRRFIP2 isoform (variant 2) inhibited the oncogenic function of coactivator-associated arginine methyltransferase 1 (CARM1) through interaction |