Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol LRRFIP2 contributors: mct - updated : 29-03-2023
HGNC name leucine rich repeat (in FLII) interacting protein 2
HGNC id 6703
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • coiled motifs interacting with the LRR domain of FLI
  • HOMOLOGY
    Homologene
    FAMILY
  • LRRFIP family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    text
  • by promoting the translocation of LRRFIP2 into cytoplasmic aggregates, UBD might block its recruitment to the membrane and its subsequent role in NFKB1 activation through TLR4 stimulation
  • basic FUNCTION
  • plays an important role in transducing Wnt signals
  • positively regulate cytokine production in macrophages, suggesting a functional role in TLR4-mediated inflammatory response
  • positively regulates NFKB and macrophage cytokine production after lipopolysaccharide
  • signal regulator, that modulates the time course-dependent changes in NFKB activity through its dynamic interaction with the TLR adaptor protein, MYD88
  • FLII and LRRFIP2 repress caspase-1 activation, which could be restored through the severing of actin filaments in a Ca2+-dependent process
  • both LRRFIP2 and FLII control the localization of NLRP3 with F-actin as well as the activity of NLRP3 inflammasome
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • FLI binding
  • interacts with DVL3 to increase the cellular levels of beta-catenin and activate beta-catenin/LEF/TCF-dependent transcriptional activity
  • MYD88 interacting with LRRFIP2 and LRRFIP1, and both are positive regulators of NF-kappaB activity
  • binds to MYD88 through its serine-rich domain (phosphorylation at serine 202 was found to regulate the dynamics of the LRRFIP2-MYD88 interaction, which in turn modulated the strength and duration of TLR4 signaling)
  • LRRFIP2 is involved in NFKB1 activation following stimulation of TLR4
  • LRRFIP2 and TOR1AIP2 are FATylation substrates
  • LRRFIP2 enhances the interaction between FLII and CASP1, facilitating the inhibitory effect of FLII on CASP1 activation
  • FLII is recruited to the NLRP3 inflammasome by leucine-rich repeat FliI-interaction protein 2 (LRRFIP2), an NLRP3-associated protein
  • LRRFIP2 and FLII is required for the co-localization of the NLRP3 and F-actin as well as for the inhibition of NLRP3 inflammasome activity
  • LRRFIP2 is regulated by epithelial splicing regulatory protein 1 (ESRP1) and this is correlated with metastatic potential of gastric cancer cells
  • epithelial LRRFIP2 isoform (variant 2) inhibited the oncogenic function of coactivator-associated arginine methyltransferase 1 (CARM1) through interaction
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    deletion, comprising exons 17-19 of the MLH1 gene and exons 26-29 of the LRRFIP2 gene in Lynch syndrome
    tumoral fusion      
    LRRFIP2-RAF1 fusion identified in an acral melanoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS