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FLASH GENE
Symbol GNAL contributors: mct/npt - updated : 03-01-2017
HGNC name guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
HGNC id 4388
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Endocrineneuroendocrinepituitary  highly
Hearing/Equilibriumear   highly
Nervousbrain    
Reproductivemale systemtestis   
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
Epithelialsensoryolfactory  
Lymphoid    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a GTPase domain made of three regions named switches 1, 2 and 3 and including the sites for guanine nucleotide binding and effector interaction
  • an helical domain
  • mono polymer heteromer , trimer
    HOMOLOGY
    Homologene
    FAMILY
  • G-alpha family
  • G(s) subfamily
  • CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • alpha stimulating activity, olfactory type
  • involved as modulators or transducers in various transmembrane signaling systems
  • may be involved in some aspect of visual transduction, and in mediating the effect of one or more hormones/neurotransmitters
  • GNAL-encoded protein is important for dopamine D1 receptor function and odorant signal transduction
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heteromeric G protein complex, with 3units: alpha, beta and gamma
  • the alpha chain contains the guanine nucleotide binding site
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • guanine nucleotide binding
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DYT25
    Susceptibility
  • to bipolar disorder and schizophrenia
  • possible contribution in the susceptibility to ADHD, with possible involvement of parent-of-origin effects (Laurin 2008)
  • Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS