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FLASH GENE
Symbol AGAP1 contributors: mct/npt - updated : 08-04-2015
HGNC name ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
HGNC id 16922
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon highly
 mouthtongue   
 pharynx   highly
Nervousnerve   highly
Reproductivefemale systembreastmammary gland highly
Visualeye    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • ATP/GTP binding site motif A (P-loop)
  • three ANK repeat
  • a ARF-GAP domain
  • a G-protein-like domain (GLD) with homology to Ras superfamily proteins
  • a PH domain
  • HOMOLOGY
    intraspecies paralog to CENTG1
    Homologene
    FAMILY
  • RAS superfamily
  • centaurin gamma-like family
  • CATEGORY signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • small GTPase mediating PI3K related Arf signalling
  • GTPase-activating protein for the adp ribosylation factor family
  • potential role in integrating signals from ARF, NO/cGMP, and tyrosine kinase signaling pathways
  • guanosine triphosphatase activating protein involved in the regulation of endosome function
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • nuclear PI3K
  • interacting with G protein-coupled receptor kinases
  • associated with paxillin
  • also interacts with PIX exchange factors
  • associate with the adaptor protein complex AP-3 and regulate the function of AP-3 endosome
  • direct physical interaction between CHRM5 and the AP-3 adaptor complex regulator AGAP1
  • AGAP1 and AGAP2 can bind to RHOA
  • cell & other
    REGULATION
    Other allosterically regulated through protein binding to the GLD domain
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to autism
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS