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FLASH GENE

Symbol

DOCK9

contributors: mct - updated : 09-03-2011

HGNC name	dedicator of cytokinesis 9
HGNC id	14132

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive intestine       lowly   liver       lowly Nervous brain limbic system hippocampus   moderately Homo sapiens   brain forebrain cerebral cortex     Homo sapiens Respiratory lung       moderately Urinary kidney       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text	placenta, highly
	strongly expressed in the developing brain

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N-terminal CZH1 domain, conserved among CZH proteins, and the Pleckstrin homology domain are involved in membrane localization, CDC42 activation, and regulation of dendrite growth
	a DHR-2 (CZH-2) domain

mono polymer

complex

HOMOLOGY

interspecies

homolog to rattus TRG protein

intraspecies

paralog to DOCK11 (52p100))

Homologene

FAMILY	superfamily of guanine nucleotide exchange factors for Rho GTPases
	Dock180-related family of proteins

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,cytosolic

basic FUNCTION	CDC42 guanine nucleotide exchange factor, having potential guanyl-nucleotide release factor activity
	implicated in cell migration, phagocytosis of apoptotic cells, T-cell activation and neurite outgrowth, and probably arose relatively early in eukaryotic evolution
	specific guanine-nucleotide exchange factor (GEF) for CDC42
	plays an important role in dendrite growth in hippocampal neurons through activation of CDC42

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

dimerizes via the CDC42-binding CZH2 domain

INTERACTION

DNA

RNA

small molecule

protein	interacts with CDC42 via the CZH2 doamin
	interacting with Rac2 and Cdc42 (specifically recognize Rac2 and Cdc42 through its switch 1 as well as â2-â3 regions)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   promoted dendrite growth

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS