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FLASH GENE
Symbol NELFA contributors: mct - updated : 01-04-2015
HGNC name negative elongation factor complex member A
HGNC id 12768
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text tissues
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a hydrophilic N terminus
  • a transmembrane segment (1TM)
  • a hydrophilic C terminus
  • two nuclear localization signals (NLS)
  • HOMOLOGY
    interspecies ortholog to murine Whsc
    intraspecies paralog to WHSC1
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • may be involved in the regulation of RNA polymerase II transcription elongation
  • important role of NELFA, NELFB in controlling RNA polymerase II (Pol II) pausing in transcription
  • NELFA and NELFB are each shown to act independently as competitive decelerators at two steps after the site of glucocorticoid receptor (GR) action and before or at the site of reporter gene activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component member of the NELF protein complex
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) WHS , WHSCR
    Susceptibility
    Variant & Polymorphism
    Candidate gene Wolf-Hirschhorn syndrome candidate gene 2
    Marker
    Therapy target
    ANIMAL & CELL MODELS