SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
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| intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
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| intracellular,nucleus,nucleoplasm
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| text
| dynamically localizes to interphase but not mitotic centrosomes |
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located at the centrosomes during interphase  |
| basic FUNCTION
| dual specificity serine/threonine-tyrosine phosphatase, involved in cell cycle function and in tumorigenesis |
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involved in the exit of cell mitosis and initiation of DNA replication |
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its upregulation prevents targeting of exocyst and SNARE complexes to the midbody, both essential for abscission to occur 5) |
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CDC14A phosphatase prevents premature activation of CDK1 regulating CDC25A and CDC25B at the entry into mitosis 3) |
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down-regulates CDC25 activity at the G2/M transition to prevent premature activation of CDK1-Cyclin B1 complexes and untimely entry into mitosis |
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CDC14A phosphatase plays a role in cell cycle control in higher eukaryotes |
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play a role in the regulation of the centrosome cycle, mitosis, and cytokinesis, thereby influencing chromosome partitioning and genomic stability in cells |
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counteracts CDK1-cyclin B1 activity through WEE1 dephosphorylation |
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redundancy between CDC14B and CDC14A in DNA Double-Strand Break Repair repair |
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role for CDC14A in cell migration and adhesion that is clearly distinct from the mitotic and cytokinesis functions of Cdc14/Flp1 in budding and fission yeast |
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is the second DFNB gene reported to be involved in the control of kinocilium growth |
