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FLASH GENE
Symbol RNF14 contributors: mct/npt - updated : 02-07-2008
HGNC name ring finger protein 14
HGNC id 10058
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
Endocrineadrenal gland   predominantly
 parathyroid   highly
Nervousnerve   highly
Reproductivefemale systemuterus   
 male systemtestis   
 male systemprostate   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a RING (C3HC4-type) zinc finger motif
  • conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY
  • RING finger protein family
  • CATEGORY transcription factor , signaling hormone
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • coactivator of AR mediated transactivation in prostate, effect inhibited by a RNF14 (ARA54) dominant negative mutation
  • androgen receptor (AR) co-activator that enhances AR-dependent transcriptional activation
  • playing a role in the regulation of cyclin D1 expression in the absence of AR stimulation in cancer cells
  • might participate in enhancing cell cycle progression and cell proliferation via induction of cyclin D1 (CCND1)(Kikuchi 2007)
  • androgen receptor (AR) co-activator that enhances AR-dependent transcriptional activation (Kikuchi 2007)
  • may play an important role in testicular development and spermatogenesis in humans (Lan 2008)
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    decreased expression is a feature of nonobstructive azoospermia (Lan 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS