SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,cytosolic
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text
| peripheral plasma membrane protein |
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activation of RasGRP1 requires its translocation to membranes, which can be directly mediated by either its PT or C1 domains |
basic FUNCTION
| guanine nucleotide releasing (exchange) protein 1, RAS activator |
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involved in Ras activation crucial for lymphocyte development and effector function (Roose 2007) |
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orchestrates Ras signaling in two ways, by activating Ras directly andby facilitating priming of SOS1 with RasGTP that binds the allosteric pocket (Roose 2007) |
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essential in T cell receptor-mediated Ras-Erk activation (Liu 2007) |
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essential regulator of mast cell function (Liu 2007) |
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plays an essential role in NK cell effector functions (Lee 2009) |
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might act as an important bridge between phospholipase-gamma activation and NK cell effector functions via the Ras-MAPK pathway (Lee 2009) |
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RASGRP1 and GRB2/SOS1 are insulators of signals that lead to RAS activation induced by different stimuli, rather than cooperating downstream of the TCRA |
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physiological relevance of the tail domain in RASGRP1 function and control of ERK signaling |
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required for ERK activation downstream of CXCR4 signaling |
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important regulator of proliferation and differentiation at the thymic beta-selection checkpoint and functions downstream of CXCR4 to activate the Ras/MAPK pathway |
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RASGRP1 and SOS1 are RAS-specific nucleotide exchange factors that have distinct roles in lymphocyte development |
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RASGRP1 upregulates signaling from RAS and contributes to epidermal tumorigenesis by increasing the total dosage of active RAS |
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creates a negative feedback loop that limits proliferative EGFR-SOS1-RAS signals in colorectal carcinoma cells |
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is an important guanine nucleotide exchange factor and activator of the RAS-MAPK pathway following T cell antigen receptor (TCR) signaling |
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is a guanine-nucleotide-exchange factor essential for MAP-kinase mediated signaling in lymphocytes |