basic FUNCTION
| involved in the signal-mediated expression in developing and mature catecholaminergic cells and neuradrenergic neurons and regulating ARIX during nervous system development |
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playing a major role in the patterning of the autonomous ventilation system and in the autonomic nervous system |
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transcription factors crucial in the development of neural-crest-derived cells, leading to ANS (autonomic nervous system) specific neuronal lineages |
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regulates its own expression by a transcriptional auto-regulatory mechanism |
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master regulator genes for peripheral SNS differentiation |
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drives ALK gene transcription by directly binding its promoter, which therefore represents a novel PHOX2B target) |
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recruited to different nodes in the genetic architecture of cell differentiation, while maintaining control over a visceral program |
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visceral sensory ganglia and the nucleus of the solitary tract all depend for their formation on the pan-visceral homeodomain transcription factor PHOX2B, also required in efferent neurons to the viscera |
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HOXB5 and PHOX2B, regulating enteric neural crest cells (ENCCs) proliferation, migration and differentiation could be risk factors for Hirschsprung disease (HSCR) |